Few health-related topics have generated more controversy than the subject of e-cigarettes and their potential to reduce the burden of tobacco-related disease in the United States weighed against the alarming rise of youth use and increased youth nicotine dependence. This session will review the changing landscape of the variety of tobacco products marketed in the United States and review current evidence of the risks and harms associated with e-cigarette use by youth as well as the risks and potential benefits for current adult smokers. Evidence-based prevention practices will be presented and legislative and regulatory policy will be discussed.